ASSOCIATION OF D-DIMER PROFILE TO SEVERITY OF TERRITORIAL ISCHEMIC STROKE IN BANTEN REGIONAL PUBLIC HOSPITAL
Abstract
Ischemic stroke become the most common cause of mortality and disability for elderly in Indonesia. Territorial ischemic stroke are often associated with the presence of blood clots that clog blood vessels in the brain. There were somehow association in different studies between increased levels of d-dimer as a fibrinolysis factor and the severity of territorial ischemic stroke which evaluated by using National Institutes of Health Stroke Scale (NIHSS) scores. This study aimed to analyze the association of d-dimer profile to the severity of territorial ischemic stroke. A Cross sectional study was conducted by taking secondary data retrospectively through medical records at the Medical Record and Radiolgy Installation at Banten Regional Public Hospital. D-dimer profile was categorized with a cutoff point 1000 ng/mL and NIHSS score was categorized with a cutoff point 10. The statistical analysis test used in this study was Fischer Exact Test. Forty-One of territorial ischemic stroke patients data were included in this study. Territorial ischemic stroke patients were mostly in the age group of 51—60 years with 16 patients (39%), males with 22 patients (53,7%), education in elementary school with 14 patients (34,1%), and territorial ischemic at left brain hemisphere precisely on frontal lobe with 14 patients (34,1%), temporal lobe with 15 patients (36,6%), and parietal lobe with 15 patients (36,6%). There was statistically significant association (p = 0,016) between the d-dimer profile and severity of territorial ischemic stroke (OR 9,6; 95% CI (1,5—60,6)). Early abnormal d-dimer levels on admission cause worsening of the condition in patients with territorial ischemic stroke based on NIHSS scores.
Keywords
Full Text:
PDFReferences
Abbas, N. I., Sayed, O., Samir, S., & Abeed, N. (2021). D-dimer level is correlated with prognosis, infarct size, and NIHSS in acute ischemic stroke patients. Indian Journal of Critical Care Medicine, 25(2), 193–198. https://doi.org/10.5005/jp-journals-10071-23744
Anindhita, T., & Prawiroharjo, P. (2017). Penurunan Kesadaran. In T. Aninditha & W. Wiratman (Eds.), Buku ajar neurologi jilid 1 (1st ed., pp. 16–35). Penerbit Kedokteran Indonesia.
Baehr, M., & Frotscher, M. (2012). Duus’ topical diagnosis in neurology (5th ed.). Thieme.
Balqis, B., Sumardiyono, S., & Handayani, S. (2022). Hubungan antara prevalensi hipertensi, prevalensi DM, dengan prevalensi stroke di indonesia (analisis data riskesdas profil kesehatan 2018). Jurnal Kesehatan Masyarakat, 10(3), 379–384. https://doi.org/10.14710/jkm.v10i3.33243
Bellesini, M., Robert-Ebadi, H., Combescure, C., Dedionigi, C., Le Gal, G., & Righini, M. (2021). D-dimer to rule out venous thromboembolism during pregnancy: a systematic review and meta-analysis. Journal of Thrombosis and Haemostasis, 19(10), 2454–2467. https://doi.org/10.1111/jth.15432
Dinas Kesehatan Provinsi Banten. (2021). Profil kesehatan provinsi banten 2021. https://dinkes.bantenprov.go.id/storage/dinkes/files/1109/Profil Kesehatan/Profil Kesehatan Banten Tahun 2021.pdf
Goyal, D., Sharma, P., & Sharma, A. (2023). Assessment of D-dimer levels in stroke patients. Journal of Cardiovascular Disease, 14(01), 3783–3787.
Kogan, E., Twyman, K., Heap, J., Milentijevic, D., Lin, J. H., & Alberts, M. (2020). Assessing stroke severity using electronic health record data: a machine learning approach. BMC Medical Informatics and Decision Making, 20(1), 1–8. https://doi.org/10.1186/s12911-019-1010-x
Mesiano, T. (2017). Peningkatan tekanan intrakranial. In T. Anindhita & W. Wiratman (Eds.), Buku ajar neurologi jilid 1 (1st ed., pp. 36–44). Penerbit Kedokteran Indonesia.
Misra, S., Montaner, J., Ramiro, L., Arora, R., Talwar, P., Nath, M., Kumar, A., Kumar, P., Pandit, A. K., Mohania, D., Prasad, K., & Vibha, D. (2020). Blood biomarkers for the diagnosis and differentiation of stroke: a systematic review and meta-analysis. International Journal of Stroke, 15(7), 704–721. https://doi.org/10.1177/1747493020946157
Ohara, T., Farhoudi, M., Bang, O. Y., Koga, M., & Demchuk, A. M. (2020). The emerging value of serum D-dimer measurement in the work-up and management of ischemic stroke. International Journal of Stroke, 15(2), 122–131. https://doi.org/10.1177/1747493019876538
Prayoga, M., Fibriani, A. R., & Lestari, N. (2017). Perbedaan tingkat defisit neurologis pada stroke iskemik lesi hemisfer kiri Dan kanan. Biomedika, 8(2). https://doi.org/10.23917/biomedika.v8i2.2916
Ramos-Pachón, A., López-Cancio, E., Bustamante, A., Pérez De La Ossa, N., Millán, M., Hernández-Pérez, M., Garcia-Berrocoso, T., Cardona, P., Rubiera, M., Serena, J., Ustrell, X., Garcés, M., Terceño, M., Dávalos, A., & Montaner, J. (2021). D-Dimer as predictor of large vessel occlusion in acute ischemic stroke. Stroke, 52(3), 852–858. https://doi.org/10.1161/STROKEAHA.120.031657
Rasyid, A., Hidayat, R., Harris, S., Kurniawan, M., & Mesiano, T. (2017). Stroke iskemik. In T. Aninditha & W. Wiratman (Eds.), Buku ajar neurologi jilid 2 (1st ed., pp. 452–475). Penerbit Kedokteran Indonesia.
Rexrode, K. M., Madsen, T. E., Yu, A. Y. X., Carcel, C., Lichtman, J. H., & Miller, E. C. (2022). The impact of sex and gender on stroke. Circulation Research, 130(4), 512–528. https://doi.org/10.1161/CIRCRESAHA.121.319915
Riset Kesehatan Dasar. (2018). Laporan nasional riskesdas 2018. In Lembaga Penerbit Balitbangkes.
Sato, T., Sato, S., Yamagami, H., Komatsu, T., Mizoguchi, T., Yoshimoto, T., Takagi, M., Ihara, M., Koga, M., Iwata, H., Matsushima, M., Toyoda, K., & Iguchi, Y. (2020). D-dimer level and outcome of minor ischemic stroke with large vessel occlusion. Journal of the Neurological Sciences, 413(September 2019), 116814. https://doi.org/10.1016/j.jns.2020.116814
Sherwood, L. (2016). Human physiology: from cells to systems. In Cengage Learning (9th ed.). Cengage Learning. https://doi.org/10.1113/jphysiol.1994.sp020394
Teja, C. M. O., Imelda Februati Ester Manurung, & Tira, D. S. (2022). Faktor yang berhubungan dengan kejadian stroke pada pasien di RSUD dr. Ben Mboi. Hospital Majapahit (JURNAL ILMIAH KESEHATAN POLITEKNIK KESEHATAN MAJAPAHIT MOJOKERTO), 14(2), 238–249. https://doi.org/10.55316/hm.v14i2.824
The Institute For Health Metrics and Evaluation. (2019). Indonesia. University of Washington. https://www.healthdata.org/research-analysis/health-by-location/profiles/indonesia
Utama, Y. A., & Nainggolan, S. S. (2022). Faktor resiko yang mempengaruhi kejadian stroke: sebuah tinjauan sistematis. Jurnal Ilmiah Universitas Batanghari Jambi, 22(1), 549. https://doi.org/10.33087/jiubj.v22i1.1950
WHO. (2012). Guidelines for management of stroke. WHO. https://extranet.who.int/ncdccs/Data/MNG_D1_1. Clinical guideline of Acute Stroke .pdf
WHO. (2024). WHO Data. https://data.who.int/indicators
World Stroke Organization. (2022). Global Stroke Fact Sheet 2022. In World Stroke Organization (WSO) (Vol. 13). https://www.world-stroke.org/assets/downloads/WSO_Global_Stroke_Fact_Sheet.pdf
Yamanie, N., Chalik Sjaaf, A., Felistia, Y., Harry Susanto, N., Diana, A., Lamuri, A., & Miftahussurur, M. (2023). High socioeconomic status is associated with stroke severity among stroke patients in the National Brain Centre Hospital, Jakarta, Indonesia. Preventive Medicine Reports, 32(6), 102170. https://doi.org/10.1016/j.pmedr.2023.102170
Yohana, Y., Rahayu, C., & Destriana, B. S. (2020). Hubungan nilai d-dimer dan LDL kolesterol pada penderita stroke iskemik di RSUD Budhi Asih Jakarta Timur. Anakes : Jurnal Ilmiah Analis Kesehatan, 6(2), 114–125. https://doi.org/10.37012/anakes.v6i2.362
Zhang, L., Long, Y., Xiao, H., Yang, J., Toulon, P., & Zhang, Z. (2018). Use of D-dimer in oral anticoagulation therapy. International Journal of Laboratory Hematology, 40(5), 503–507. https://doi.org/10.1111/ijlh.12864
Zhuo, Y., Qu, Y., Wu, J., Huang, X., Yuan, W., Lee, J., Yang, Z., & Zee, B. (2021). Estimation of stroke severity with national institutes of health stroke scale grading and retinal features: a cross-sectional study. Medicine (United States), 100(31), E26846. https://doi.org/10.1097/MD.0000000000026846
DOI: http://dx.doi.org/10.62870/tmj.v3i2.25429
Refbacks
- There are currently no refbacks.
Copyright (c) 2024 Marshavina Damayanti, Ahmad Irwan Rusmana, Louisa Ivana Utami
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
Manage by Faculty of Medicine, Universitas Sultan Ageng Tiryatasa
Publish by: Universitas Sultan Ageng Tiryatasa
Address : Jl. Raya Palka No.Km 3, Panancangan, Kec. Cipocok Jaya, Serang, Banten 42124, Indonesia
Tirtayasa Medical Journal (E-ISSN 2809-5111) is licensed under a Creative Commons Attribution 4.0 International License. Preserved in LOCKSS, through PKP Private LOCKSS Network program.